The building was designed by Kazuyo Sejima and Ryue Nishizawa, and features a simple structure of glass and steel. The building is divided into three areas: the Collection Exhibition Zone, the Special Exhibition Zone, and the Exchange Zone.

The Collection Exhibition Zone exhibits a wide range of collections, from works by modern art masters to works by up-and-coming artists. The Special Exhibition Zone hosts special exhibitions introducing contemporary art from Japan and abroad. The Exchange Zone hosts a variety of cultural activities, including workshops and lectures.

Interactive installations such as the representative work "Swimming Pool" are also popular.

The Exchange Zone is equipped with the cafe restaurant Fusion21, a museum shop, and an art library. A variety of programs, including workshops and lectures, are held every day, making it popular with families and students.

[Ranking of popular art works]
1. Swimming Pool / Leandro Erlich
2. Color Activity House / Olafur Eliasson
3. L’Origine du monde / Anish Kapoor
4. The Man Who Measures the Clouds / Jan Fabre
5. Blue Planet Sky / James Turrell
6. The Green Bridge / Patrick Blanc
7. You Regenerate Yourself / Pipilotti Rist
8. Crankfeld No. 3 for the Arena / Florian Krall
9. Circle (Spherical Pavilion) / SANAA
10. Motet for 40 Voices / Janet Cardiff